Recently, Orthotek Lab published an innovative study in the journal "WEAR," which compared the wear particles of tibial inserts made from VE/HXLPE and UHMWPE knee prostheses under in vitro conditions.

Knee arthroplasty is an important treatment option for joint injuries, and its success largely depends on the wear resistance of the materials used. For a long time, ultra-high molecular weight polyethylene (UHMWPE) has been widely used due to its excellent biocompatibility and wear resistance; however, the tiny particles generated from its wear can activate macrophages, triggering an inflammatory response that accelerates the failure of artificial joints. In contrast, vitamin E-stabilized highly cross-linked polyethylene (VE/HXLPE) has attracted significant attention from researchers due to its unique antioxidant properties and lower wear rates.

Addressing the limited research on the wear of VE/HXLPE, this study utilized principal component analysis (PCA) techniques to meticulously classify the morphology of wear particles and explored the formation mechanisms of different morphologies. Additionally, the study calculated the functional biological activity (FBA) of VE/HXLPE wear particles to predict potential biological responses. The results revealed significant differences in particle size, shape distribution, and biological activity between VE/HXLPE and UHMWPE wear particles. These findings provide important experimental evidence for the application of VE/HXLPE as a material for artificial joints.

As a top journal in the field of tribology, "WEAR" has long been committed to advancing the research on material wear properties. The publication of the latest research findings in "WEAR" further demonstrates that Orthotek Lab has mastered various methods for extracting wear particles from implants and assessing their safety, providing reliable evaluation services and data analysis for assessing the clinical safety of artificial joints. Orthotek Lab consistently adheres to the work principle of being "accountable for results" and maintains a working attitude of "upholding integrity and innovation" in the evaluation and testing of implant safety. For more information on Orthotek Lab's research progress and the latest technological achievements, please follow our official WeChat account.

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